Fibrates for cholesterol

Fibrates are the derivatives of fibric acid. These are used for lowering the cholesterol level in the blood. These drugs have the potential to affect the lipid profile of the body. The process by which Fibrates lower the cholesterol level is a bit complicated. Fibrates are believed to produce a protein substance called peroxisome proliferator-activated receptor alpha (PPAR-alpha). It activates an enzyme called lipoprotein lipase. This enzyme is responsible for the declination of apolipoprotein C-III levels in the body. The decreased level of apolipoprotein C-III reduces the low density lipoprotein and triglycerides level in the body. Low density lipoproteins are the type of cholesterol which is harmful for the body. They clog the blood vessel. It increases the blood pressure triggering many heart diseases.  The decreased level of apolipoprotein C-III also increases the breakdown of lipids this increases the level of high density lipoprotein which is good for health. Using Fibrates alone can lower your cholesterol level in the blood. However, to get significant results it can be combined with other lipid lowering agents.   The main advantage of Fibrates is they mostly reduce the levels of triglycerides in the body.  They also reduce low density lipoprotein and high density lipoprotein to some extent.