Synthesis of cholesterol |
Actually about 80% of the body cholesterol is produced by your body itself and only 20% of cholesterol in the blood comes from your diet. About 20–25% of total cholesterol is produced by liver and the other regions where cholesterol is synthesized are the intestines, adrenal glands, and reproductive organs. Usually the synthesis of cholesterol within the body begins with a molecule of acetyl CoA and acetoacetyl-CoA. These two molecules get dehydrated and form 3-hydroxy-3-methylglutaryl CoA (HMG-CoA). This 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) molecule is then reduced to mevalonate with the help of an enzyme called HMG-CoA reductase. |
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